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Título

VAGINAL DEVELOPMENT DURING 2ND GESTATIONAL TRIMESTER: TRANSLATIONAL STUDY IN HUMAN FEMALE FETUSES WITH DISORDERS OF THE NEURAL TUBE

Resumo

Purpose: One of the most common malformations of the central nervous system is related to embryonic neural tube alterations. We hypothesized that anencephaly affects the development of the vagina during the human second trimester of pregnancy. Our study compared the biometric parameters of the vagina in human female fetuses with neural tube defects.

Methods: In our study, 34 female fetuses were analyzed, 22 normal and 12 anencephalic, aged between 12 and 22 weeks post-conception (WPC). After dissection of the pelvis and individualization of the genital tract, we evaluated the length and width of the vagina using the Image J software. We compared the means statistically using the Wilcoxon-Mann-Whitney test and performed linear regression.

Results: We do not identify statistical significance between the groups for the measurements of vaginal length (Control:3.12-18.33mm/mean=9.08mm/SD+-3.77 vs. Anencephalic:2.91-13.10mm/mean=7.24mm/SD+-2.28, p=0.3469) and vaginal width (Control: 1.04- 4.86mm/mean= 2.71mm/SD+- 0.94 vs. Anencephalic: 1.35-3.17mm/mean= 2.13mm/SD +- 0.65; p =0.2503). The linear regression analysis indicated that 78,57% significance was found in the correlations in normocephalic fetuses and 57,14% significance in anencephalic fetuses (12.3 to 18.6 WPC).

Conclusions: We do not found differences in the length and width of the vagina in anencephalic fetuses but the vaginal length and width shows a lesser tendency to growth in the anencephalic fetuses during the second trimester suggesting that anencephaly is can impact the development of the vagina.

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Keywords: Anencephaly; Urogenital system; Fetuses; Histomorphometric analysis.