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Título

MORPHOLOGICAL STUDY OF THE UTERUS IN HUMAN FETUSES ­ DOES ANENCEPHALY CORRELATE WITH DIFFERENCES IN THAT ORGANOGENESIS?

Resumo

Purpose: One of the most common malformations of the central nervous system is related to embryonic neural tube alterations. We hypothesized that anencephaly affects the development of the uterus during the human second trimester of pregnancy. The objective of this study was to study the biometric parameters of the uterus in fetuses with anencephaly and compare them with normocephalic fetuses at that important .

Methods: In our study, 34 female fetuses were analyzed, 22 normal and 12 anencephalic, aged between 12 and 22 weeks post-conception (WPC). After dissection of the pelvis and individualization of the genital tract, we evaluated the length and width of the uterus using the Image J software. We compared the means statistically using the Wilcoxon-Mann-Whitney test and performed linear regression.

Results: We do not identify statistical significance between the groups for the measurements of uterus length (Control: 2.02-6.36mm/mean=3.59mm/SD+-1.43 vs. Anencephalic: 1.71-5.44mm/mean=2.97mm/SD+-1.21, p=0.1070) and uterus width (Control: 1.99-7.91mm/mean= 3.84mm/SD+- 1.27 vs. Anencephalic: 2.08-6.48mm/mean= 3.65mm/SD +- 1.23; p =0.3360). The linear regression analysis indicated that 80% significance was found in the correlations in normocephalic fetuses (12.9 to 22.6 WPC) and 40% significance in anencephalic fetuses (12.3 to 18.6 WPC).

Conclusions: We do not find statistical differences in the length and width of the uterus in anencephalic fetuses compared to the control group but uterine length and width shows a lesser tendency to growth in the anencephalic fetuses during the second trimester suggesting that anencephaly can impact the development of the uterus.

Palavras Chave ( separado por ; )

Anencephaly; Urogenital system; Fetuses; Morphometric analysis